5 Intravenous magnesium directly affects myocardial potassium channels, has voltage-dependent and indirect effects on calcium and sodium channels, prolongs the PR interval, and increases the refractory period of antegrade atrioventricular node conduction. The attention on magnesium as a potential antiarrhythmic agent is founded on a small number of physiological assessments in human and animal models. 3, 4 Identifying practical and effective methods for managing AF is a clinical imperative. 2 AF is not only prevalent in the general population (≈3%, with much higher rates in older patients) but also a frequent comorbidity and risk factor in patients with a range of cardiovascular conditions, including heart failure and after cardiac surgery. This issue is clinically important in view of the high burden that AF poses, the increasing incidence of AF, and the association of AF with adverse long-term clinical outcomes. 1 However, like many interventions before it, supplementing magnesium levels does not necessarily lead to a successful cardioversion or better prevention of AF in high-risk groups. Low magnesium levels have been implicated as a risk factor for the development of atrial fibrillation (AF).
About Circ: Arrhythmia and Electrophysiology.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.
Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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